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pentobarbital will reduce the level or effect of ziprasidone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unidentified.pentobarbital will lessen the level or effect of osilodrostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or effect of darifenacin by influencing hep